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20191007 - Perspectives on the Development, Evaluation and Application of in silico approaches for predicting toxicity (PANWAT)
Citation:
Patlewicz, G. 20191007 - Perspectives on the Development, Evaluation and Application of in silico approaches for predicting toxicity (PANWAT). 2019 Annual Meeting of the Pacific Nortwest Association of Toxicologists (PANWAT), Boise, Idaho, October 06 - 07, 2019. https://doi.org/10.23645/epacomptox.10299371
Impact/Purpose:
Invited presentation to the 2019 Annual Meeting of the PANWAT (Pacific Northwest) Regional Chapter of the Society of Toxicology in October 2019. This presentation offers a perspective of the current status of non-testing approaches, their evolution in light of the advances in high-throughput approaches and constructs such as adverse outcome pathways.
Description:
Changes in regulations in the industrial chemicals and cosmetics sectors in recent years have prompted a significant number of advances in the development, application, and assessment of non-testing approaches, such as (Q)SARs and read-across. Many efforts have also been undertaken to establish guiding principles for performing read-across within category and analogue approaches. This presentation offers a perspective, as taken from these sectors, of the current status of non-testing approaches, their evolution in light of the advances in high-throughput approaches and constructs such as adverse outcome pathways. The presentation will illustrate these perspectives drawing from 2 main approaches – 1) Exposure based waiving approaches such as the Threshold of Toxicological Concern (TTC) and their utility in risk-based prioritization decision contexts and 2) Read-across approaches – transitioning towards a hybrid harmonized objective read-across workflow and the application of chemical grouping approaches to identify and evaluate PFAS (per and polyfluorinated substances) toxicities. This abstract does not necessarily represent U.S. EPA policy.
URLs/Downloads:
DOI: 20191007 - Perspectives on the Development, Evaluation and Application of in silico approaches for predicting toxicity (PANWAT)
PATLEWICZ_PANWAT_UPDATED031019.PDF (PDF, NA pp, 7307.056 KB, about PDF)